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Kids First: Novel Cancer Susceptibility in Families (from BASIC3)
Kids First Data Resource
Data Resource:  Kids First Data Resource
Point of Contact:  
Allison Heath,  
Project

About This Dataset
This project includes data derived from subjects enrolled in the BASIC3 (Baylor College of Medicine Advancing Sequencing in Childhood Cancer Care) study. BASIC3 is a National Genome Human Research Institute (NHGRI) and National Cancer Institute-funded Clinical Sequencing Exploratory Research (CSER) consortium project that focused on prospective implementation of clinical whole exome sequencing in the pediatric oncology clinic. The primary study objective were to integrate information from CLIA-certified germline and tumor exome sequencing into the care of newly diagnosed solid tumor patients at Texas Children's Cancer Center, and to perform parallel evaluation of the impact of tumor and germline exomes on families and physicians. Blood and frozen tumor (if available) samples were collected from children undergoing surgery or biopsy of newly diagnosed solid tumors and subjected to exome sequencing in a CLIA-certified laboratory. Germline and tumor (if applicable) exome sequencing reports were generated and submitted into the electronic health record and returned to each patient/family by their primary oncologist. In addition to the clinical exome sequencing, specific (optional) consent was requested for research sequencing studies. If this consent was obtained then research studies of some of the children and parents participating in the BASIC3 study (including tumor transcriptome and whole genome sequencing of blood and/or tumor) are performed.
Core Data Elements
Number of Cases
718
Case Sex
Female (354); Male (364)
Case Age At Diagnosis
0 to 4 years (90); 5 to 9 years (67); 10 to 14 years (61); 15 to 19 years (29); Pediatric and Young Adult (<40 years) (471)
Case Race
American Indian or Alaska Native (23); Asian (21); Black or African American (54); More Than One Race (25); Not Reorted (217); White (378)
Case Ethnicity
Hispanic or Latino (268); Not Hispanic or Latino (315); Not Reported (135)
Case Disease Diagnosis
Anaplastic Ependymoma (4); Ewing Sarcoma (12); Glioblastoma (5); Hepatoblastoma (7); Medulloblastoma (14); Mixed Germ Cell Tumor (7); Neoplasms (344); Neuroblastoma (26); Osteosarcoma (14); Other (245); Pilocytic Astrocytoma (17); Wilms Tumor (23)
Case Proband
Yes (247); No (471)
Number of Samples
276
Sample Assay Method
Whole Genome Sequencing (276)
Additional Data Elements
DBGAP STUDY IDENTIFIER
DATA REPOSITORY
Grant Information
U01HG006485
Charts
Male (364); Female (354)
364Male